Compagnone M, Taglieri N, Celeski M, et al. - Among consecutive patients undergoing percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease between January 2003 and December 2015, researchers performed this inquiry to determine how elective, uncomplicated target lesion revascularization (TLR) could influence long-term cardiac mortality post-PCI for ULMCA disease. The participants were recruited from an interventional center in Northern Italy. Cases with presentation with cardiogenic shock, ST-segment elevation myocardial infarction, as well as patients undergoing urgent or complicated TLR were eliminated. In patients undergoing elective, uncomplicated TLR vs in those not undergoing TLR, a total of 23 and 50 cardiac deaths were reported, respectively, following a median follow-up of 5.5 years. Overall, findings revealed increased risk of long-term cardiac mortality in relation to elective, uncomplicated TLR following PCI of ULMCA disease. Improved survival in these patients may potentially be achieved by decreasing the risk of TLR following PCI of ULMCA disease.