Impact of diabetes mellitus on epithelial ovarian cancer survival
BMC Cancer Dec 18, 2018
Akhavan S, et al. - In this retrospective cohort study of 215 patients with epithelial ovarian cancer (EOC) diagnosed between 2009 and 2016, researchers determined the impact of diabetes mellitus (DM) on overall survival (OS) and progression free survival (PFS). Standard demographic, pathologic and DM diagnosis data were reviewed and after adjusting for age, body mass index (BMI), parity, stage, grade, histology, debulking status, hypertension (HTN), menopause status and neoadjuant chemotherapy, the link between disease status and survival was examined by using Cox regression. Findings showed that, PFS and OS could be negatively influenced by DM in EOC patients independent of the effect of other variables. The unadjusted and adjusted hazard ratio (HR) for PFS and DM was 5.69 and 2.73, respectively; and for the association between OS time and DM was 4.76 and 3.93, respectively.
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