Podmore B, et al. - Researchers explored the link between different comorbid conditions on safety (short-term outcomes) and effectiveness (long-term outcomes) in patients undergoing hip and knee replacement surgery through a systematic review and meta-analysis. They searched Medline, Embase and CINAHL Plus up to May 2017. In this analysis, 70 studies were involved with 16 (23%) reporting on at least 100,000 patients and 9 (13%) were of high quality. Little evidence was found that patients with comorbid conditions benefit significantly less from hip and knee replacement in terms of quality of life, function and pain after surgery than patients without comorbid conditions. The study findings suggested that comorbid conditions have an impact on safety but little impact on the effectiveness of hip and knee replacement surgery.