Kanaya A, et al. - Factors determining propofol pharmacokinetics were investigated in this study. Propofol pharmacokinetics was shown to be affected by body mass index (BMI) after its administration as a single intravenous injection, while no impact of UGT1A9 and CYP2B6 SNPs, other clinical factors, and hemodynamic variables was observed. This indicated that BMI is an independent factor associated with propofol pharmacokinetics in several potential covariates.