Oliva M, Huang SH, Xu W, et al. - Researchers used the eighth edition tumour-node-metastasis (TNM) staging classification (TNM8) and determined how cause-specific survival (CSS) and overall survival (OS) in human papillomavirus–positive (HPV+) oropharyngeal carcinoma (OPSCC) are influenced by cisplatin cumulative dose (CDDP-D) and smoking pack-years (PYs). Between 2005 and 2015, patients with HPV+ OPSCC who received high-dose CDDP and intensity-modulated radiotherapy at Princess Margaret Cancer Centre were reviewed. According to CDDP-D < 200/ = 200/ > 200 mg/m² stratified by TNM8, comparisons were performed for CSS and OS. Findings revealed no correlation of CDDP-D with either survival or disease-specific outcomes in this large and homogeneous HPV+ cohort, although stageIII HPV+ OPSCC taking CDDP-D < 200 mg/m² had reduced CSS. They found a negative association of smoking PYs with OS but not with CSS.