Azab B, et al. - Researchers investigated the relationship between chemoradiation-to-surgery (CRT-S) interval and pathological complete response rate (pCR) and overall survival (OS) in patients with esophageal cancer. Using National Cancer Data Base patients with CRT followed by surgery, they studied CRT-S interval as a continuous (weeks) and categorical variable (quintiles: 15–37, 38–45, 46–53, 54–64, and 65–90 days, with n = 1,016, 1,063, 1,081, 1,083, and 938 patients, respectively). Outcomes revealed higher pCR rate with longer CRT-S interval, however, surgery seemed optimal less than 65 days after CRT to avoid worse 90-day mortality and attain better OS. Prolonged CRT-S interval showed no effect on OS among patients with squamous cell carcinoma and those with pCR.