Sharma SK, et al. - Researchers report 1-year results of the Multi-center Prospective Study to Evaluate Outcomes of Moderate to Severely Calcified Coronary Lesions (MACE-Trial, a prospective, multicenter, observational clinical study) which assessed the influence of calcification on procedural and long-term percutaneous coronary intervention outcomes, including lesion success, procedural success, and 1-year major adverse cardiac events (MACEs). Participants were 350 patients enrolled at 33 sites from September 2013 to September 2015. According to lesion calcification, core lab assessed subject stratification (none/mild [N = 133], moderate [N = 99], and severe [N = 114]). Lesion success was found to be significantly influenced by the presence of severe calcification ([83.3%] vs none/mild calcification [94.7%]) and procedural success ([86.8%] vs moderate [95.0%], and none/mild [97.7%]). Also, 1-year MACE rates were found to be related to presence of calcification in subjects with none/mild (4.7%), moderate (8.7%), and severe (24.4%) calcification; there was no difference between none/mild and moderate. Predictors of 30-day and 1-year MACE were severe calcification and decreasing eGFR. Overall, significantly worse outcomes were seen in patients with severe calcification vs those without. Moderate calcium led to similar outcomes as none/mild calcium; this was dissimilar from the findings in previous retrospective studies.