Sun Y, et al. – This study aimed at assessing the effect of obesity, measured by body mass index (BMI), on tumor response, surgical outcome in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (nCRT) and radical surgery. As per findings, obesity appeared associated with poorer T downstaging and Rectal Cancer Regression Grade, and thus poor local control in LARC following nCRT in Asian patients. This suggested the necessity for more effective treatment strategies to improve treatment outcome for obese patients with LARC.