Chen H, et al. - In this observational and physiologic study, data were assessed to analyze the influence of the change in airway pressure on intracranial pressure, cerebral perfusion, or cerebral oxygenation. They observed no alterations in intracranial pressure, cerebral oxygenation, or perfusion with positive-pressure ventilation in the normal brain. But, they explained the changes in intracranial pressure due to altered airway pressure with cerebral venous Starling resistor in case of injured brains. Conclusively, they suggested that negative-pressure ventilation could cause improvement in cerebral perfusion as well as oxygenation and reduction in intracranial pressure.