Vanassche T, et al. - This paper encompassed an investigation of the effects of advanced age, comorbidities, and polypharmacy on the efficacy and safety of edoxaban and warfarin in patients with venous thromboembolism (VTE). The findings revealed that a once-daily fixed dose of edoxaban was more effective and at least as safe as warfarin among high-risk VTE patients, who were detected via by older age, more comorbidities, and polypharmacy.