Gaberel T, et al. - In a mouse model of subarachnoid hemorrhage (SAH), researchers assessed the role of an enzyme known to cause cell death in ischemic stroke, called 12/15-lipoxygenase (12/15-LOX), on brain injury. Using a direct blood injection technique, C57Bl6 wild-type mice and Alox15 knockout mice were subjected to SAH. According to findings, 12/15-LOX is overexpressed in macrophages following SAH in mice and inhibiting the 12/15-LOX pathway reduces brain injury and improves neurological outcome. Researchers feel 12/15-LOX could be a new therapeutic target for reducing brain injury following SAH.