Järvinen KM, et al. - Via analyzing relevant literature data, researchers determined how sensitization is influenced by breast milk-induced immunomodulation. They also looked at the possible mechanisms of action. They searched PubMed for animal and human studies (all recent and some older key publications) that evaluated breastfeeding or breast milk composition in food allergy. According to the findings, attenuated risk of food allergy in the infant was observed in relation to high levels of human milk immune factors (IgA, cytokines, oligosaccharides). Antigens, transforming growth factor β, and immunocomplexes offered protection, the potential mechanisms of which were highlighted in animal studies, however, their significance is poorly understood in humans. Human milk, possibly by influencing the infant gut microbiome or directly impacting the immune system, provides protection against allergy development.