Shehata WA, Hammam MA, Ayad A, et al. - In plaque psoriasis, cornulin might be involved in keratinocyte hyperproliferation and inflammation and could be of great worth as a treatment target.

• This is a case-control study with 30 cases with plaque psoriasis and another 30 as controls, to assess Cornulin expression values in lesional and perilesional psoriatic skin vs the control group's skin via immunohistochemistry.

• A stepwise pattern of significant Cornulin overexpression in keratinocytes was noted, in the epidermis, beginning from controls (34.00 ± 23.65) to lesional (62.59 ± 23.93) passing through perilesional skin (36.52 ± 18.49).

• A stepwise pattern of the significance of Cornulin was also observed, initiating from 4 in controls (13.3% for both) to 28 lesional cases (93.3%) and 18 (60.0%) passing through 17 perilesional skin cases (56.7%) and 5 (16.7%) for inflammatory cells and adnexa, respectively.

• Results revealed a significant link between lesional epidermal Cornulin's strong intensity and a higher H-score and both hyperkeratosis and parakeratosis.