Bwire GM, et al. - In this cross-sectional study of 220 children, immunoglobulin G (IgG) responses against specific Plasmodium falciparum antigens were examined in 110 children with homozygous sickle cell trait (HbSS) vs 110 with normal hemoglobin (HbAA). This study assessing the degree of IgG levels directed against PfEBA-175, Pfg27, and yPfs28C in children with homozygous sickle cell trait and those with normal hemoglobin, was undertaken for the first time in this setting. Children with HbSS showed more enhanced humoral response against specific Plasmodium falciparum parasite antigens than HbAA. Age, body weight and hemoglobin level did not influence the levels of IgG responses to Plasmodium falciparum antigens in both groups, except for HbAA group, which showed a significant increase in IgG against Pfg27 by 0.004 ng/ml with 1 g/dl increase in Hb level.