Kalinowska-Lyszczarz A, et al. - During this research, authors contemplated the existence of a tie-up between immune cell neurotrophin production with damage severity in neuropsychiatric systemic lupus erythematosus (NPSLE). Data shed light on the connection between immune cell BDNF and NGF levels with subcortical atrophy in NPSLE. It was discovered that higher BDNF levels correlated with higher midsagittal atrophy, which possibly depicted compensatory mechanisms, upregulating BDNF when neuroprotection was required.