Morales-Cabeza C, et al. - This study involves characterization of immediate hypersensitivity reactions (IHRs) to iodinated contrast media (ICMs) in a Spanish tertiary hospital during a 7-year period, mainly focusing on clinical and allergologic features of these reactions. As per findings, in a low percentage of patients with IHRs to ICMs, a possible underlying specific IgE-mediated mechanism by positive skin test result was identified. Data showed the utility of controlled challenge test (CCT) based on skin test results for detecting an alternative non–cross-reactive ICM in these patients.