Marino MA, et al. - Using the fifth edition of the Breast Imaging Reporting and Data System (BI-RADS), researchers evaluated imaging phenotypes of familial breast cancer on mammography (MG), ultrasound (US), and magnetic resonance imaging (MRI) and examined inter-observer agreement as well as correlated imaging phenotypes with risk status, histopathology, and molecular subtypes derived by immunohistochemical surrogate. Participants in the study were 49 women who were diagnosed with breast cancer within the high-risk screening program. Findings revealed that imaging phenotypes of breast cancer with BI-RADS were malignant in high-risk women. The most sensitive test for cancer detection was MRI of the breast. They found that tumor localization appears to be influenced by the risk status.