Ye J, et al. – This study was designed to compare the clinical characteristics and imaging features on contrast–enhanced ultrasound (CEUS) of hepatitis B virus (HBV)–related combined hepatocellular–cholangiocarcinoma (CHC) and hepatocellular carcinoma (HCC). Furthermore, a receiver operating characteristic curve was plotted and the area under the curve was 0.740. It was considered that combined hepatocellular–cholangiocarcinoma should be watched for in HBV–infected patients with liver tumor manifesting peripheral irregular rim–like enhancement on contrast–enhanced ultrasound, accompanied by CA19–9 elevation.