Wei W, Huang J, Ma Y, et al. - Researchers conducted the study for examining the involvement of the key molecules of IL‐1 (interleukin‐1) signaling pathways in pediatric patients with asthma. Differentially expressed genes (DEGs) associated with IL‐1 signaling pathways were identified with RNA‐seq from peripheral blood samples obtained from asthmatic or healthy children and were further confirmed in clinical peripheral blood samples. Among the DEGs detected by RNA‐seq, eight signal transducers correlated with the IL‐1 signaling network, ie, IL‐1RN, IL‐1β, IL‐1RAP, IRAK3, IL‐1R1, MYD88, IRAK2, and PELI1, were observed to be substantially upregulated in children with asthma. Such findings show that IL‐1RN, IL‐1RAP, IRAK3, and PELI1, which are signal transducers of the IL‐1 signaling pathway, could serve as biomarkers for childhood asthma pathogenesis and for possible asthma therapeutic targets.