Hessam S, et al. - This trial substantiated the expression of interleukin (IL)-36α, β, γ, and the antagonistic cytokines IL-36Ra, IL-37, and IL38 in the skin of hidradenitis suppurativa (HS) patients. The data shed light on the potential involvement of IL-36 cytokines in the inflammatory network of HS and a dysbalance between the agonistic and antagonistic cytokines in HS skin.

Methods

• This trial examined the skin samples from lesional and corresponding perilesional HS skin, and from healthy controls.
• The quantitative real-time RT-PCR was utilized for this purpose.
• A scrutiny was carried out of a subset of skin samples via immunohistochemistry, in order to gauge the PCR results of IL-36α, β, and γ.

Results

• Substantially higher expression levels of IL-36α, β, γ, and IL-36Ra were disclosed in the lesional HS skin than the healthy controls.
• In contrast to the healthy controls, IL-37 and IL-38 were considerably higher in perilesional HS skin and decreased in lesional HS skin.