Pestel J, et al. - Given obese people have adipose tissue infiltrated with many immune cells, including Th17 (T-helper 17) lymphocytes and monocytes/macrophages, and the role of obese adipose-derived stem cells (ob-ASC) and adipocytes (AD) in the mediation of inflammation via promotion of Th17 cells and activation of monocytes has also been earlier reported, and impaired ob-ASC adipogenesis and AD insulin response was the consequence of such an inflammation, so, researchers focused on the role of IL-17A in the impairment of these functions, by using a potent human anti-IL17A monoclonal antibody ie, Secukinumab. Findings revealed no major role of IL-17A in the impairment of adipogenesis and/or insulin resistance mediated by an inflammatory environment. Nonetheless, the contribution of IL-17A to the propagation of inflammation in human obese adipose tissues was suggested. This implies that anti-IL17A mAb may confer benefit in cases with inflammatory pathologies, where obesity contributes to poorer response to biologic therapies.