Totte JEE, et al. - Authors sought to profile IgG antibodies against 55 S. aureus antigens in sera of children with a mild-to-severe atopic dermatitis (AD) and to evaluate the association between IgG levels and disease severity. Children with AD from 2 interventional study cohorts were included: the Shared Medical Appointment (SMA) cohort and the older DAVOS cohort. In young children, experts noted an association of the severity of AD with an IgG response directed against S. aureus antigens with mainly immunomodulatory functions. Mainly secreted proteins with immunomodulatory functions were targeted with the associated IgG antibodies.