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IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma

Clinical & Experimental Allergy Jun 16, 2018

Patelis A, et al. - Given that sensitization to food allergens and sensitization to airborne allergens has been reported to have independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma, researchers explored the link between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics, aged 17-76 years, from the Swedish GA2LEN study. They found the associations between sensitization to food allergens and several local and systemic type 2 inflammation markers, such as FeNO, serum eosinophil cationic protein and periostin. Therefore, asthma management might be improved via an improved understanding and interpretation of inflammatory markers, which might be gained via evaluation of the profile of allergic sensitization, including to food allergens.
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