Derraik JGB, et al. - In children with idiopathic short stature (ISS) and of normal stature (NS) over the birth weight range, researchers compared growth hormone (GH) sensitivity to an IGF-I generation test. For this investigation, they studied 46 prepubertal children (~7.1 years) born at term, both ISS (n=23; 74% boys) and NS (n=23; 57% boys). In both NS and ISS children, a progressive reduction in birth weight SDS was linked to a decrease in GH sensitivity. In association with lowering birth weight, the lower IGF-I response to rhGH stimulation shows that ISS children at the lower end of the birth weight spectrum might have partial GH resistance, which might contribute to their lower growth.