Fedoriw Y, Selitsky S, Montgomery ND, et al. - This study was intended to present the profiling of Diffuse Large B-cell lymphoma (DLBCL) from Malawi, aiming to elucidate tumor biology and identify clinically meaningful biomarkers specifically for sub-Saharan Africa (SSA). This study included a total of 59 cases of DLBCL (32 HIV+/27 HIV−) in the Kamuzu Central Hospital Lymphoma Study were characterized, of which 54 (92%) were negative for Epstein–Barr virus. This research gives among the first molecular characterizations of DLBCL from SSA, shows marked gene expression differences by HIV status, and distinguishes genomic and immunophenotypic characteristics that can inform future basic and clinical investigations.