Lipton RB, et al. - Researchers wanted to determine natural subgroups of people with migraine based on profiles of comorbidities and concomitant conditions, hereafter referred to as comorbidities by conducting a prospective web-based survey study, the Chronic Migraine Epidemiology and Outcomes Study. Using latent class analysis (LCA) modeling, they identified 8 natural subgroups of persons with migraine based on comorbidity profiles (Class 1, Most Comorbidities; Class 2, Respiratory/Psychiatric; Class 3, Respiratory/Pain; Class 4, Respiratory; Class 5, Psychiatric; Class 6, Cardiovascular; Class 7, Pain; Class 8, Fewest Comorbidities). The classes differed in terms of demographic and headache features, which were not used to form the classes.