Gupta N, Weitzman RE, Murad F, et al. - Findings demonstrate an 8% likelihood of developing poor outcomes in BWH (Brigham and Women's Hospital) T2a-high cutaneous squamous cell carcinomas (CSCCs).

• In this 17-year retrospective multi-institutional cohort study, a predictive model based on tumor characteristics was constructed to unveil risk factors related to poor outcomes (nodal metastasis, distant metastases, and disease-specific deaths) in BWH T2a CSCC.

• Poor outcomes were best predicted by the presence of 1 major criterion (primary tumor diameter ≥40 mm, invasion depth beyond subcutaneous fat, poor differentiation, or large-caliber perineural invasion) and ≥ 1 minor criterion (invasion depth in subcutaneous fat, moderate differentiation, small-caliber perineural invasion, or lymphovascular invasion).

• The sensitivity, specificity, positive and negative predictive values yielded by the model were 7.7%, 97.4%, 33.3% and 86.1%, respectively.

• In these tumors, 5-year cumulative incidence of poor outcomes was estimated to be 8.0% (95% CI, 5.1-13.7) vs 2.8% (95% CI, 1.9-4.1) in other T2a tumors (sub-hazard ratio, 3.0; 95% CI, 1.5-5.8).