Chen C, Zhou H, Zhang X, et al. - Researchers sought to determine expression level, prognostic significance as well as potential biological role of the transcription factor zinc finger protein 704 (ZNF704) in human chondrosarcoma. They found significantly higher expression levels of ZNF704 mRNA and protein in chondrosarcoma tissues, when compared with those in the paired adjacent non-tumor tissues and benign cartilage tumors. In clinicopathological analysis, ZNF704 expression at higher levels was evident in chondrosarcoma patients with higher histological grade and advanced MSTS stage. A significant correlation between high expression of ZNF704 and a worse overall survival of chondrosarcoma patients, was also identified. Findings indicate a likely role of ZNF704 as a potent oncogene implicated in chondrosarcoma development, and ZNF704 also represents an independent prognostic marker. Thus, ZNF704 has potential as a novel biomarker and treatment target for chondrosarcoma.