Wang D, Wei G, Ma J, et al. - Given that ferroptosis is closely related to the occurrence and development of breast cancer, researchers sought to establish a ferroptosis-related prognostic gene signature for anticipating patients’ survival. In this investigation, a total of 1,076 breast cancer patients from The Cancer Genome Atlas cohort were finally recruited. This study's prognostic model is made up of nine ferroptosis-related genes (ALOX15, CISD1, CS, GCLC, GPX4, SLC7A11, EMC2, G6PD, and ACSF2). According to the findings, the ferroptosis-related prognostic signature gene could be used as a novel biomarker for predicting the prognosis of breast cancer patients. Furthermore, the authors discovered that immunotherapy may play an important role in the therapeutic schedule for breast cancer patients based on the level and difference of immune-related cells and pathways in different risk groups.