Wang MY, et al. – The physicians performed this study to apply an approach based on phase transfer entropy (PTE) and graph theory to analyze the interactions between the stereo–electroencephalography (SEEG) activities recorded in multilobar origin, in order to assess their ability to detect the epileptogenic zone (EZ) of temporal lobe epilepsies (TLE). They demonstrated that this approach could add new and valuable information, giving efficient quantitative measures useful for localizing the EZ.

• The physicians included 43 patients in this retrospective study.
• They implanted 5 to 16 (median = 12) multilead electrodes per patient.
• For each patient, a sub-set of between 10 and 32 (median = 22) bipolar derivations was selected for analysis.
• They classified the leads into the onset leads (OLs), the early propagation leads (EPLs), and the rest of the leads (RLs).

• The physicians demonstrated that a significantly different dynamic trend of the out/in ratio (more obvious in the gamma band) distinguishes the OLs from RLs in the 23 patients who were seizure-free not only during the ictal event (significant elevation), but also during the inter-, pre-, late-ictal periods, and particularly in the post-ictal (sharp decline) state.
• However, the differences between the OLs and RLs during the post-ictal period were not found in any frequency band in the 20 patients who were not-seizure-free.
• They used the dynamic trend to predict surgical outcome.
• The outcomes revealed that the sensitivity was 91% and the specificity was 70%.