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Identification of the EMT-related genes signature for predicting occurrence and progression in thyroid cancer

OncoTargets and Therapy May 28, 2021

Li Q, Jiang S, Feng T, et al. - Researchers investigated the link between epithelial–mesenchymal transition (EMT)-related genes (ERGs) features and the diagnosis as well as prognosis of thyroid cancer (TC) patients. They conducted a transcriptomic profile analysis by utilizing four datasets from Gene Expression Omnibus. They discovered 43 differentially expressed ERGs (DEERGs), and regarded 10 DEERGs as hub ERGs, which had a high degree of connectivity in the protein–protein interaction network. Disease-free survival (DFS) analysis revealed upregulations of fibronectin 1 (FN1) expression as well as integrin alpha 2 (ITGA2) expression and downregulation of receptor tyrosine kinase (KIT) expression raised risks of reduced DFS for The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) patients. By developing a prognostic risk scoring model, it was identified that the DFS of TCGA-THCA patients was significantly worse in high-risk groups. Overall, experts conclude these hub ERGs as potential biomarkers for diagnosis as well as prognosis of TC.

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