Li Y, Chen X, Li D, et al. - Analyzing the function of distinct CC chemokines in urothelial bladder cancer (BC), a significantly better prognosis of BC patients was observed in relation to high expression levels of CCL1, CCL2, CCL3, CCL4, CCL5, CCL8, CCL13, CCL15, CCL17, CCL18, CCL19, CCL22, CCL25, CCL27.

• In this study, ONCOMINE, Gene Expression Profiling Interactive Analysis, Kaplan–Meier plotter, cBioPortal, GeneMANIA, and TIMER were utilized.

• In BC patients, a significant decrease in transcriptional levels of CCL2/3/4/5/14/19/21/23 was evident.

• Expression of CCL2/11/14/18/19/21/23/24/26 was significantly related to the pathological stage of BC patients.

• Differentially expressed CC chemokines were shown to be primarily correlated with cytokine activity, chemokines receptor binding, chemotaxis, immune cell migration.

• In addition, the expression of CC chemokines were significantly correlated with infiltration of various types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells).