Arab JP, Díaz LA, Baeza N, et al. - For severe alcohol-associated hepatitis (AH), defined as MELD score > 20, the only effective therapy is corticosteroids. However, the therapy may not benefit the patients who may be too sick. Researchers herein sought for the range of MELD score within which steroids are effective treatment for AH. In this retrospective, international multi-center cohort study, a total of 3,380 adults with clinical and/or histological diagnosis of AH were included from 4 continents; median age: 49 [40-56] years; 76.5% male; 79% with underlying cirrhosis. Observations revealed correlation of using corticosteroids with improved 30-day survival. Corticosteroids were identified to yield maximum benefit in cases with a MELD score between 25-39, although a moderate benefit in survival was noted in cases with a MELD score between 22-24 and 44-51. They suggest using a MELD score > 51 to define futility of corticosteroid treatment in patients with severe AH. No sustainment of the survival benefit was noted at 90 or 180 days.