Manichaikul A, Peres LC, Wang XQ, et al. - Given a worse survival despite a lower incidence of epithelial ovarian cancer (EOC) among women of African ancestry vs women of European ancestry, researchers performed a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. Four novel loci with suggestive evidence of association with EOC were recognized; these included rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3′ of UGT2A2) and rs142091544 (5 kb 5′ of WWC1). For HGSOC, Six loci with suggestive evidence of association were identified; these included rs37792 (132 kb 5′ of follistatin [FST]), rs57403204 (81 kb 3′ of MAGEC1), rs79079890 (LOC105376360 intronic), rs66459581 (5 kb 5′ of PRPSAP1), rs116046250 (GABRG3 intronic) and rs192876988 (32 kb 3′ of GK2). In follow-up studies of the 10 identified variants, they identified an inverse association of the GK2 region SNP, rs192876988, with EOC in European ancestry women, with increased risk of ER positive breast cancer in African ancestry women and with decreased expression of GK2in HGSOC tissue from African ancestry women. A shared genetic architecture was suggested as positive associations of a European ancestry-derived polygenic risk score with EOC and HGSOC were evident in women of African ancestry. Findings thereby provide evidence that European and African ancestry women share variants for EOC and characterize novel EOC risk loci in women of African ancestry.