Yang X et al. – The study aimed at identifying novel mycobacterial antigens that would improve the sensitivity and specificity for tuberculosis (TB) diagnosis and screening of latent TB infection (LTBI). In this study, higher BfrB (bacterioferritin B)–specific IFN–γ responses were observed for PTB (Pulmonary TB) and LTBI groups compared to HCs (Healthy Controls). BfrB has potential to increase the sensitivity for LTBI screening as BfrB–specific cellular immune responses were comparable to ESAT–6/CFP–10 responses in patients with LTBI. In addition, strong BfrB–specific IFN–? release in a healthy cohort could be cautionary to identify leaky LTBI from HCs.