Yang Z, et al. - The expression of leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) in esophageal squamous carcinoma (ESCC) and its relationship with cancer stem-like cells (CSC) were examined in this analysis. For this investigation, researchers used immunohistochemistry in 166 ESCC tissue samples, as well as western blot and immunofluorescent methods in ESCC cell lines to analyze the role of LETM1 and its relationship with CSC in ESCC. The findings from the present study suggested that high expression of LETM1 indicates poor prognosis in ESCC and it could be a potential cancer stem-like cells marker in ESCC. LETM1 may also be a novel therapeutic target for the treatment of ESCC.