Kolossváry M, et al. - Researchers compared the performance of radiomic analysis to that of conventional assessment of coronary computed tomography angiography (CTA) images for the detection of invasive and radionuclide imaging markers of plaque vulnerability. The patients who had coronary CTA, sodium-fluoride positron emission tomography (NaF¹⁸-PET), intravascular ultrasound (IVUS), and optical coherence tomography (OCT) were prospectively included in this study. They evaluated 7 conventional plaque features. Using CTA images, 935 radiomic parameters were also estimated. This analysis included 44 plaques of 25 patients. Findings revealed good to excellent diagnostic accuracy of coronary CTA radiomics for detecting invasive and radionuclide imaging markers of plaque vulnerability. The performance of coronary CTA radiomics was significantly superior to conventional quantitative and qualitative high-risk plaque features. Vulnerable plaques could be more accurately identified by coronary CTA radiomics compared with conventional methods.