Shi H, Koronyo Y, Rentsendorj A, et al. - The present study reports the identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina. Assessment of postmortem retinas from a cohort of 56 human donors showed an early and progressive reduction in vascular platelet-derived growth factor receptor-β (PDGFRβ) in mild cognitive impairment (MCI) and Alzheimer disease (AD) compared with cognitively normal controls. The relationships were found between retinal vascular abnormalities and cerebral Aβ burden, cerebral amyloid angiopathy (CAA), and clinical status. The data suggested that the identification of pericyte and PDGFRβ loss accompanying improved vascular amyloidosis in Alzheimer’s retina implies compromised blood-retinal barrier integrity and presents new points for AD diagnosis and therapy.