Zhong S, et al. - This study was planned to assess the novel targets of diagnosis, therapy and prognosis for glioblastoma, as well as to verify the therapeutic effect of JNJ-7706621 regarding to glioblastoma. In comparison to human normal glial cell, glioblastoma cells expressed significantly high AURKA (Aurora kinase), nuclear division cycle 80 (NDC80), kinesin super-family protein 4A (KIF4A), and nucleolar and spindle-associated protein 1 (NUSAP1). Patients with low-expression of those four genes had a favorable prognosis. In treatment of glioblastoma patients, JNJ-7706621 proved a potential drug.