Li N, et al. - Researchers used The Cancer Genome Atlas, gene set enrichment analysis, and Cox proportional hazards regression model to develop a novel DNA repair-related gene signature that combines various genes to improve prognosis prediction in hepatocellular carcinoma (HCC). They constructed a gene signature using a set of seven genes, namely, ADA, FEN1, POLR2G, SAC3D1, SEC61A1, SF3A3, and UPF3B, which showed a significant relation to overall survival. They calculated the signature risk score, which was used to classify patients into high- and low-risk groups. The worse prognosis was seen in the high-risk group. In univariate and multivariate Cox regression analysis, this risk score signature displayed a robust prognostic performance in various subgroups based on clinicopathological characteristics, with P-values < 0.05, suggesting that it can be used as an independent prognostic indicator. Overall, a seven-gene signature associated with the DNA repair process was constructed and identified, which could predict survival in HCC. Findings revealed its efficacy for classification and for guiding clinical treatment.