Zhang L, Pu D, Liu D, et al. - In this investigation, researchers sought to identify and validate novel circulating biomarkers for early diagnosis of lung cancer. By RayBiotech antibody array, expression of 1,000 secreted proteins in 15 early lung cancer patients and 10 healthy controls’ plasma were investigated. Candidate biomarkers were identified in 371 patients with lung cancer and 388 healthy controls through SPSS analysis and validated by ELISA. To assess the diagnosis effectiveness and to establish diagnostic models, receive operating characteristic curve and binary logistic regression were conducted. Compared with healthy controls, 22 molecules expressed aberrantly in early lung cancer patients. According to combination analysis, compared with classic lung cancer biomarkers, brain angiogenesis inhibitor 1, E-Cadherin and thrombospondin-1 had better diagnostic effectiveness. The findings showed the potential status of lung cancer diagnosis of BAI-1, E-Cadherin and TSP-1.