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Hypothesis of “stroke-stop” formula: A tool for risk index determination in development of acute cerebrovascular disease in asymptomatic individuals with carotid stenosis

BMC Neurology Aug 14, 2021

Kopolovets I, Berek P, Stefanic P, et al. - Researchers proposed the hypothesis of the “Stroke-Stop” formula for better selection of patients who should be indicated for surgical treatment and will be assessed in a prospective study. Using the “Stroke-Stop” formula, they plan to do a prospective study for ipsilateral annual stroke rate in asymptomatic individuals with carotid stenosis who receive conservative therapy, in order to verify this hypothesis.

  • A cross-sectional study was conducted including a total of 70 patients with atherosclerotic ICA stenosis.

  • There was a significant increase in the risk of stroke development with the progression of ICA stenosis and elevation of Lp-PLA2 levels.

  • The risk of stroke development was significantly higher in correlation with patients with an echogenic plaque in patients with echolucent plaque.

  • Three main groups were generated: low (< 70 points), medium (70–100 points), and high (> 100 points) risk of stroke development based on calculations using the “Stroke-Stop” formula.

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