Sequeira SB, Chen DQ, Bell JE, et al. - This study was undertaken to determine if hypogonadism is correlated with increased risks of postoperative complications following total hip arthroplasty (THA). A total of 3,903 male patients with a diagnosis of hypogonadism who had primary THA from 2006 to 2012 were identified utilizing a national insurance database and compared to 20:1 matched male controls utilizing a logistic regression analysis. Findings suggested an association of hypogonadism with an increased risk of major medical complications, urinary tract infection, wound complications, deep vein thrombosis, emergency room visit, readmission, periprosthetic joint infection, dislocation, and revision following THA. A preoperative diagnosis of hypogonadism was linked to increased total reimbursement and charges by $390 and $4514, respectively. Prior to undergoing joint replacement, results from this study will influence the conversation between the patient and the provider and serve as the basis for further studies.