Hwang JJ, et al. - Researchers sought to ascertain the presence of variations in mild glucose decrements alter brain activity in regions associated with reward, motivation, and executive control in type 1 diabetes mellitus (T1DM) patients with and without hypoglycemia awareness. A progressive blunting of brain responses in cortico-striatal and fronto-parietal neurocircuits was elicited in response to mild-moderate hypoglycemia in T1DM and in particular T1DM-unaware patients. Yielded data presented implications for comprehending why individuals with impaired hypoglycemia awareness failed to respond appropriately to falling blood glucose levels.