Xu W, et al. - In this investigation, researchers analyzed the serum immunoglobulin and complement levels of newly diagnosed diffuse large B cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma in all over the world, patients in the hospital to assess their prognostic value and want a new prognostic model to be constructed. Between May 2009 and May 2018, 553 newly diagnosed DLBCL patients were involved in the investigation. By univariate and multivariate regression analyses, the connection between hypogammaglobulinemia, hypocomplementemia at diagnosis and progression-free survival (PFS), overall survival (OS) were performed. The authors concluded that PFS and OS had poor prognosis both for hypogammaglobulinemia and hypocomplementemia at diagnosis. In newly diagnosed DLBCL patients, new prognostic system immunization cumulative prognostic score+IPI could be more sensitive to predict survival.