Offersen BV, Alsner J, Nielsen HM, et al. - Since 1982, the Danish Breast Cancer Group (DBCG) has been using a dose of 50 Gy in 25 fractions (fr) as the standard regimen, given the poor outcomes using hypofractionated radiotherapy for early breast cancer, and also a renewed interest in hypofractionation has been stimulated by findings from more recent trials, therefore, researchers investigated if a dose of 40 Gy in 15 fr did not increase the occurrence of breast induration at 3 years vs a dose of 50 Gy in 25 fr in the noninferiority DBCG HYPO trial. Participants were 1,882 patients > 40 years of age who received breast-conserving surgery for node-negative breast cancer or ductal carcinoma in situ (DCIS). These patients were randomized to radiotherapy at a dose of either 50 Gy in 25 fr or 40 Gy in 15 fr. Findings revealed that more breast induration was not caused by moderately hypofractionated breast irradiation of node-negative breast cancer or DCIS vs standard fractionated therapy. There were minimal other normal tissue impacts, with similar or less frequent rates in the 40-Gy group. A low 9-year locoregional recurrence risk was observed.