Lv S, et al. - In young adults ≤ 35 years of age, researchers assessed the association and interactive effects of hyperuricemia (HUA) and smoking on coronary artery disease (CAD) risk. In this observational study, 1,113 adults (18-35 years of age) with suspected CAD who underwent coronary angiography for the first time in their institution from January 2005 to December 2015 were consecutively included. Findings demonstrated a significant association of HUA with the presence of CAD in non-smokers ≤ 35 years of age.