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Hypertensive disorders in women with peripartum cardiomyopathy: Insights from the ESC Peripartum Cardiomyopathy Registry

European Journal of Heart Failure Jun 16, 2021

Jackson AM, Petrie MC, Frogoudaki A, et al. - Women with peripartum cardiomyopathy (PPCM) with and without hypertensive disorders during pregnancy were examined for differences in phenotype and outcomes. Using the European Society of Cardiology PPCM Registry, they enrolled 735 women; 452 of these women (61.5%) had PPCM without hypertension (‘PPCM-noHTN’), 99 (13.5%) had PPCM with hypertension but without pre-eclampsia (‘PPCM-HTN’) and 184 (25.0%) had PPCM with pre-eclampsia (‘PPCM-PE’). Women with PPCM-PE had more severe symptoms, more frequent signs of heart failure, higher baseline LVEF and smaller left ventricular end diastolic diameter when compared with women with PPCM-noHTN. Women with PPCM-PE had a greater likelihood of left ventricular recovery (LVEF ≥ 50%) and an adverse neonatal outcome (composite of termination, miscarriage, low birth weight or neonatal death) when compared with women with PPCM-noHTN. These findings support the existence of differences in terms of phenotype, recovery of cardiac function and neonatal outcomes according to hypertensive status in women with PPCM.

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