Scholtens DM, et al. - In the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, an observational international investigation established links of maternal glucose with adverse perinatal outcomes. In the Follow-Up Study, researchers studied associations of maternal glycemia during pregnancy with childhood glucose outcomes. Study participants included 4,832 children (aged 10–14) whose mothers had a 75-g oral glucose tolerance test (OGTT) at around 28 weeks’ gestation. Of these, 4,160 children were assessed for glucose outcomes. Maternal fasting plasma glucose (FPG) was correlated positively with child FPG and A1C. Maternal 1-hour and 2-hour plasma glucose (PG) were positively related to child fasting, 30 minute, 1-hoour, and 2-hour PG, and A1C. Findings revealed that exposure to higher utero levels in the maternal glucose spectrum was significantly linked to childhood glucose and insulin resistance, regardless of maternal and childhood BMI and family history of diabetes.