Tuorila K, Ollila MM, Järvelin MR, et al. - In this prospective study, experts aspired to explore whether hyperandrogenemia (HA) estimated by serum testosterone (T) level and free androgen index at ages 31 and 46 is correlated with insulin resistance, insulin secretion, and abnormal glucose metabolism (AGM) by age 46. Participants in the study were 5,889 females followed at ages 31 and 46. They compared women with HA with normoandrogenic women at ages 31 and 46. At age 31, HA women demonstrated increased HOMA–IR, HOMA–B, and higher fasting insulin than normoandrogenic women after adjusting for BMI. At 46, HA women had a nonsignificant trend toward higher fasting glucose and glycated hemoglobin A1 levels. In early and middle age, hyperandrogenemia and low SHBG are associated with AGM regardless of BMI.